angiotensin converting enzyme – Communicable Diseases Research

The favorable impacts of silibinin polyphenols as adjunctive therapy in reducing the complications of COVID-19: A review of research evidence and underlying mechanisms

Review article

Published on 2022-10-012022-10-05
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar
[Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료제,

On virus and nanomaterials – Lessons learned from the innate immune system – ACE activation in the invertebrate model Enchytraeus crypticus

바이러스 및 나노물질에 관하여 - 선천적 면역계에서 배운 교훈 - 무척추동물 모델 Enchytraeus crypticus에서 ACE 활성화

Article

Published on 2022-08-152022-09-11
Journal: Journal of hazardous materials
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] ACE ACE gene ACE2 Activation angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 caused Cell Community Conserved mechanisms Corona Corona virus COVID-19 current database develop down-regulation enzyme experiment expression fold functional immune immune system Inflammatory Innate innate immune response innate immune system invertebrate invertebrates knowledge lesson mechanism Nanomaterial nanomaterials Other receptor Research respiratory responses SARS-CoV-2 Severe acute respiratory syndrome Spike proteins stress condition stress conditions stress response Stress response. Support the spike protein therapy threat Threats Total transfer triggering vertebrates virus
[DOI] 10.1016/j.jhazmat.2022.129173 PMC 바로가기 [Article Type] Article

In silico SARS-CoV-2 vaccine development for Omicron strain using reverse vaccinology

역백신학을 이용한 오미크론 균주에 대한 In silico SARS-CoV-2 백신 개발

Article

Published on 2022-08-012022-09-11
Journal: Genes & genomics
[Category] COVID19(2023년), SARS, 변종,

[키워드] 3D structure 3D Structures ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allergenicity angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antigenic antigenicity applied B cell epitope B cell epitopes B.1.1.529 binding collected coronavirus develop Efficacy effort enzyme epitope Epitopes estimation final vaccine construct Health Organization in silico MHC I MHC II molecular docking analysis Mutation non-allergenic non-toxic omicron pandemic Physicochemical properties physicochemical property predict predicted Prevent profile RaptorX reduce reverse vaccinology SARS-CoV-2 SARS-CoV-2 vaccine second secondary structure secondary structures selected severe acute respiratory syndrome Coronavirus solubility Spread stability Structure tested the vaccine Toxicity Vaccine vaccine candidate vaccine construct Vaccine design Vaccine design. Vaccines variant viral genome sequences virus VoC was performed were used WHO wild type World Health Organization
[DOI] 10.1007/s13258-022-01255-8 PMC 바로가기 [Article Type] Article

Molecular and computational analysis of spike protein of newly emerged omicron variant in comparison to the delta variant of SARS-CoV-2 in Iraq

이라크에서 SARS-CoV-2의 델타 변이체와 비교하여 새로 출현한 오미크론 변이체의 스파이크 단백질의 분자 및 컴퓨터 분석

Article

Published on 2022-08-012022-09-11
Journal: Molecular biology reports
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 acute respiratory syndrome coronavirus Affect amino acids angiotensin angiotensin converting enzyme binding affinity bioinformatics computational analysis computational tool computational tools concerning contagious contributing to COVID-19 Delta delta variant Delta variants disorder Docking studies docking study engage enzyme greater Health higher affinity human ACE2 human angiotensin converting enzyme 2 hydrophobic amino acid identify Interaction Iraq less molecular molecular docking omicron Omicron variant Omicron variants pathogenicity PCR Phylogenetic analysis physical physical and chemical properties predicted qPCR RBD RBD region Receptor binding domain respiratory SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2. Sequencing severe acute respiratory syndrome Coronavirus Spike protein stability the spike protein Transmissibility Transmission Vaccine variant variant of SARS-CoV-2 variants variants of concern virus were used WHO
[DOI] 10.1007/s11033-022-07545-4 PMC 바로가기 [Article Type] Article

Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System

새로운 안지오텐신 수용체 차단 약물, 비사르탄, COVID-19 치료와 관련된 작용: 안지오텐신 수용체의 편향 작용 및 레닌 안지오텐신 시스템에서 네프릴리신의 유익한 효과

Article

Published on 2022-07-292022-09-11
Journal: Molecules
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] 3CLpro ACE2 Action activated activating active site Agonism ANG Ang II angiotensin angiotensin converting enzyme Angiotensin II angiotensin II receptor blockers (ARBS) angiotensin II receptors Angiotensin receptor blockers anionic ARB/NEP docking ARBs AT1 AT2 biased agonism binding biphenyl bisartans blocker blocking cells charge relay system (CRS) complementary COVID-19 COVID-19 virus DNA driven by edema Effect endopeptidase enzyme Evidence explained furin G protein Human genome humoral hypertension in silico inhibit inhibiting inverse agonist involved modulating molecular molecular dynamics Molecular dynamics (MD) mRNA neprilysin novel opposite peptide peptides Protein Pulmonary edema RAS receptor Receptor Blockers receptors Renin SARS-COV-2 infection Sartans. Screening Serine serine proteases switching System tetrazole this system Treatment Vasoactive viral entry Zinc
[DOI] 10.3390/molecules27154854 PMC 바로가기 [Article Type] Article

Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures

SARS-CoV-2 스파이크 단백질과 DNA-펩티드 나노구조의 결합 상호작용 특성 규명

Article

Published on 2022-07-272022-09-11
Journal: Scientific Reports
[Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] acute respiratory syndrome Amino acid amino acid sequence analyte angiotensin angiotensin converting enzyme Beta binding binding interaction binding interactions binding modes capture characterization complement concentrations Corona virus DNA ELISA enzyme full-length spike protein geometric hACE2 immunosorbent inactivated increase in Interaction investigated moiety mono peptide Protein binding quantified Quantitative RBD receptor SARS-CoV-2 SARS-CoV-2 spike protein sequence Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus shown Spike protein Spike proteins subunit subunits tested the spike protein trimeric trivalent variant variations virus virus virus strain viruses while wild type
[DOI] 10.1038/s41598-022-16914-9 PMC 바로가기 [Article Type] Article

Predictive Models of within- and between-Species SARS-CoV-2 Transmissibility

종 내 및 종 간 SARS-CoV-2 전염성 예측 모델

Article

Published on 2022-07-192022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 Amino acid angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme 2 (ACE2) Angiotensin-converting enzyme angiotensin-converting enzyme 2 complex Coronaviridae Coronaviridae family coronavirus enzyme expected feature host receptor hosts human ACE2 receptor humans in silico infect Infection interact interfacing residues Model Mutation pandemic Positive selection positively correlated predict predicted Prediction model Protein receptor complex replacement reported reservoir residue residues S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 variant SARS-CoV-2 variants shown species spike spike glycoprotein spike glycoprotein (S). subtype Subtypes susceptible the Coronaviridae the SARS-CoV-2 thought Transmissibility transmissibility of SARS-CoV-2 virus
[DOI] 10.3390/v14071565 PMC 바로가기 [Article Type] Article

Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19

중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19

Review

Published on 2022-07-122022-09-11
Journal: Cells
[Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells mesenchymal stem cells. MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread
[DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review

Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera

쥐 감염 및 인간 면역 혈청 탈출에 중요한 SARS-CoV-2 스파이크 돌연변이의 특성화

Article

Published on 2022-07-072022-09-11
Journal: Nature Communications
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] (alpha ACE-2 Alpha angiotensin angiotensin converting enzyme B.1.1.529 B.1.1.7 B.1.351 Beta cause characterization convalescent disease Efficiency enzyme Gamma genetic background H655Y immune infect Infection insertion Lineage lineages lung mice Mild Mild disease morbidity murine Mutation N genes N501Y neutralization not affect obese omicron Omicron variants P.1 post vaccination receptor Receptor binding domain S gene S protein SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 Spike mutation SARS-CoV-2 variant SARS-CoV-2 variants sera Transmissibility USA-WA1/2020 variants virus viruses VOCs wild type
[DOI] 10.1038/s41467-022-30763-0 PMC 바로가기 [Article Type] Article

Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infections

SARS-CoV-2 감염의 동반 질환 관련 단백질에 대한 Momordica dioica의 예측 의약 대사 산물

Article

Published on 2022-07-012022-09-11
Journal: Journal of biomolecular structure & dynamics
[Category] COVID19(2023년), SARS, 치료제,

[키워드] ACE-2 ADME angiotensin angiotensin converting enzyme antidiabetic Antiviral binding binding affinities Blood brain barrier cardiovascular disease catechin comorbid comorbid condition comorbid conditions Comorbidity Compound correlated DDP4 diabetes dipeptidyl peptidase docking score DPP4 drugs enzyme exhibited Favipiravir flavonoid flavonoids gastrointestinal tract hederagenin Human Hydroxychloroquine immune immunomodulatory activities in silico in vitro investigated involved kidney ligands metabolite molecular molecular docking Momordica Momordica dioica oleanolic acid plant predicted protease Proteases Protein quercetin RdRP receptor reflect Remdesivir reported RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 main protease significant interaction Spike protein the SARS-CoV-2 therapeutic viral entry viral proteases.
[DOI] 10.1080/07391102.2020.1868340 PMC 바로가기 [Article Type] Article